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Chitosan microparticles as injectable scaffolds for tissue engineering
Author(s) -
García Cruz Dunia Mercedes,
Escobar Ivirico Jorge Luis,
Gomes Manuela M.,
Gómez Ribelles Jose Luis,
Sánchez Manuel Salmerón,
Reis Rui L.,
Mano João F.
Publication year - 2008
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.106
Subject(s) - genipin , chitosan , tissue engineering , regenerative medicine , biomedical engineering , viability assay , stromal cell , chemistry , transplantation , cell , surgery , medicine , pathology , biochemistry
The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three‐dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine. Copyright © 2008 John Wiley & Sons, Ltd.