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A Simple and High‐Accuracy PID ‐Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer
Author(s) -
Shikano Akihiro,
Tonthat Loi,
Yabukami Shin
Publication year - 2021
Publication title -
ieej transactions on electrical and electronic engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 1931-4981
pISSN - 1931-4973
DOI - 10.1002/tee.23361
Subject(s) - hyperthermia , thermometer , temperature control , overshoot (microwave communication) , pid controller , temperature measurement , materials science , biomedical engineering , nuclear magnetic resonance , computer science , medicine , thermodynamics , physics , telecommunications
Magnetic hyperthermia is very promising cancer therapy in which heating temperature is expected to be a key determinant for its success. Herein, we present a simple, real‐time, and high‐accuracy proportional‐integral‐derivative‐based temperature control system for magnetic hyperthermia using widely‐used induction heater and fiber optic thermometer. Our in vitro result shows that the temperature of clinically‐approved Resovist® (0.5 ml) was accurately controlled with very small overshoot (e.g., 45.0 ± 0.07 °C and 55.0 ± 0.11°C for low‐ and high‐temperature magnetic hyperthermia). Our system has the potential to be used for magnetic hyperthermia either alone or together with other cancer treatment modalities for basic and clinical studies. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.