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Novel structure of microneedle arrays for the transdermal drug delivery applications
Author(s) -
Miki Hirofumi,
Nishikata Ryota,
Minehira Koji,
Tsuchitani Shigeki
Publication year - 2019
Publication title -
ieej transactions on electrical and electronic engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 1931-4981
pISSN - 1931-4973
DOI - 10.1002/tee.22775
Subject(s) - transdermal , stratum corneum , multiphysics , materials science , polyvinyl alcohol , microelectromechanical systems , biocompatible material , substrate (aquarium) , drug delivery , gelatin , quad flat no leads package , coating , nanotechnology , adhesive , biomedical engineering , composite material , engineering , chemistry , layer (electronics) , structural engineering , medicine , biochemistry , oceanography , pathology , finite element method , geology , pharmacology
Microneedle (MN) arrays can increase the number of compounds amenable to transdermal drug delivery systems by penetrating the skin's protective stratum corneum. However, the dosage is extremely limited especially in the coating‐type MN because of its small surface area. We proposed and fabricated a novel structure of an MN array device having a flexible large area and strong MN arrays where island‐like firm foundations were arranged on a flexible substrate and dense MN arrays were arranged on these foundations. Structural analysis was performed using COMSOL Multiphysics, and a prototype was realized by applying MEMS (Micro Electronic Mechanical Systems) technology and casting mold method using biocompatible and low‐cost gelatin and polyvinyl alcohol (PVA) as the MN array material. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.