Premium
Development of an Artificial Lipid‐Based Membrane Sensor with High Selectivity and Sensitivity to the Bitterness of Drugs and with High Correlation with Sensory Score
Author(s) -
Kobayashi Yoshikazu,
Hamada Hikari,
Yamaguchi Yasuhiro,
Ikezaki Hidekazu,
Toko Kiyoshi
Publication year - 2009
Publication title -
ieej transactions on electrical and electronic engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 1931-4981
pISSN - 1931-4973
DOI - 10.1002/tee.20469
Subject(s) - plasticizer , adipate , selectivity , phosphoric acid , membrane , chemistry , materials science , chromatography , organic chemistry , biochemistry , polymer chemistry , catalysis
Abstract This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1‐butylpentyl) adipate (BBPA), bis(2‐ethylhexyl) sebacate (BEHS), phosphoric acid tris(2‐ethylhexyl) ester (PTEH), and tributyl o‐acetylcitrate (TBAC) as a plasticizer and phosphoric acid di‐n‐decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter‐masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.