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Cover Feature: Electrochemical Installation of CFH 2 −, CF 2 H−, CF 3 −, and Perfluoroalkyl Groups into Small Organic Molecules (Chem. Rec. 9/2021)
Author(s) -
Kisukuri Camila M.,
Fernandes Vitor A.,
Delgado José A. C.,
Häring Andreas P.,
Paixão Márcio W.,
Waldvogel Siegfried R.
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202180905
Subject(s) - electrosynthesis , electrochemistry , chemistry , molecule , organic molecules , combinatorial chemistry , cover (algebra) , radical , small molecule , organic chemistry , electrode , engineering , mechanical engineering , biochemistry
The cover picture displays fluoroalkyl radicals as reactive intermediates in the electrochemical (per)fluoroalkylation and representative examples of electrochemically fluoroalkylated small molecules. The installation of fluoroalkyl moieties into drug candidates significantly promotes their potency. Electrosynthesis is a sustainable and powerful technology to tackle this challenging synthetic task. Consequently, electrochemical fluoroalkylation of small organic molecules has become a vivid area of research, which is surveyed by S. R. Waldvogel and co‐workers in their Record Review (DOI: 10.1002/tcr.202100065).