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Transition Metal‐Catalyzed C−H Oxidation of Saturated Hydrocarbons with Molecular Oxygen
Author(s) -
Komiya Naruyoshi,
Murahashi ShunIchi
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202100154
Subject(s) - chemistry , catalysis , molecular oxygen , acetonitrile , acetaldehyde , oxygen , aldehyde , transition metal , photochemistry , inorganic chemistry , organic chemistry , ethanol
The C−H oxidation of saturated hydrocarbons to the corresponding alcohols and ketones can be performed efficiently at room temperature with molecular oxygen (1 atm) in the presence of acetaldehyde and catalysts such as Fe, Cu(OH) 2 , and CuCl 2 ‐18‐crown‐6 complex. Moreover, extremely high turnover numbers (>27,000) have been obtained for the C−H oxidation of saturated hydrocarbons with molecular oxygen (1 atm) using a combination of Cu(OAc) 2 and acetonitrile at 70 °C. Related oxidation reactions such as epoxidation, Baeyer‐Villiger reaction, acetoxylation of β‐lactams with molecular oxygen and a suitable aldehyde at room temperature are described.