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Electrochemical Installation of CFH 2 −, CF 2 H−, CF 3 −, and Perfluoroalkyl Groups into Small Organic Molecules
Author(s) -
Kisukuri Camila M.,
Fernandes Vitor A.,
Delgado José A. C.,
Häring Andreas P.,
Paixão Márcio W.,
Waldvogel Siegfried R.
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202100065
Subject(s) - electrosynthesis , electrochemistry , cathodic protection , trifluoromethylation , molecule , organic molecules , alkyl , organic synthesis , chemistry , combinatorial chemistry , redox , nanotechnology , organic chemistry , materials science , catalysis , electrode , trifluoromethyl
Abstract Electrosynthesis can be considered a powerful and sustainable methodology for the synthesis of small organic molecules. Due to its intrinsic ability to generate highly reactive species under mild conditions by anodic oxidation or cathodic reduction, electrosynthesis is particularly interesting for otherwise challenging transformations. One such challenge is the installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science due to their unique physicochemical features. Unsurprisingly, several electrochemical fluoroalkylation methods have been established. In this review, we survey recent developments and established methods in the field of electrochemical mono‐, di‐, and trifluoromethylation, and perfluoroalkylation of small organic molecules.