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Electrochemically Driven Radical Reactions: From Direct Electrolysis to Molecular Catalysis
Author(s) -
Chen Na,
Xu HaiChao
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202100048
Subject(s) - chemistry , radical , electrochemistry , alkene , catalysis , electrocatalyst , photochemistry , intramolecular force , electrolysis , heteroatom , combinatorial chemistry , radical ion , ionic liquid , photoredox catalysis , organic chemistry , ion , photocatalysis , electrode , electrolyte , ring (chemistry)
Organic radicals are versatile synthetic intermediates that provide reactivities and selectivities complementary to ionic species. Despite its long history, electrochemically driven radical reactions remain limited in scope. In the past few years, there have been dramatic increase in research activity in organic electrochemistry. We have been developing electrochemical and electrophotocatalytic methods for the generation and synthetic utilization of organic radicals. In our studies, various radical species such as alkene and arene radical cations and carbon‐ and heteroatom‐centered radicals are generated from readily available precursors through direct electrolysis, molecular electrocatalysis or molecular electrophotocatalysis. These radical species undergo various inter‐ and intramolecular oxidative transformations to rapidly increase molecular complexity. The simultaneous occurrence of anodic oxidation and cathodic proton reduction allows the oxidative reactions to proceed through H 2 evolution without external chemical oxidants.