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Approaches to Cyclophane‐Types of Cyclopeptide Alkaloids
Author(s) -
Wang Yuanhao,
Joullié Madeleine M.
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202100017
Subject(s) - depsipeptide , regioselectivity , cyclic peptide , chemistry , combinatorial chemistry , stereochemistry , peptide , organic chemistry , biochemistry , catalysis
The cyclopeptide alkaloids are cyclic depsipeptides incorporating cyclophanes with polyamide units 13‐, 14‐ and 15‐membered macrocyclic systems. Although various pharmacological activities have been ascribed to cyclopeptide alkaloids from plants of the Rhamnacea family, these studies have been hampered by their low availability due to the lack of reasonable amounts distributed in nature. Therefore, novel and efficient synthetic approaches should be an important aim, which inspired us to examine how to diversely construct the unique structures of this type of natural products. In this account, several typical strategies are presented in terms of efficient, stereocontrolled and regioselective synthesis of cyclopeptide alkaloids.