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Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment
Author(s) -
Tiburcius Steffi,
Krishnan Kannan,
Yang JaeHun,
Hashemi Fatemeh,
Singh Gurwinder,
Radhakrishnan Deepika,
Trinh Hoang Trung,
Verrills Nicole M.,
Karakoti Ajay,
Vinu Ajayan
Publication year - 2021
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.202000104
Subject(s) - drug delivery , prostate cancer , drug , targeted drug delivery , medicine , cancer , nanotechnology , risk analysis (engineering) , computer science , pharmacology , materials science
Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer‐related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non‐specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the design of a suitable drug delivery system that can ensure targeted delivery and minimise side effects. Silica based nanoparticles (SBNPs) have emerged as one of the most versatile materials for drug delivery due to their tunable porosities, high surface area and tremendous capacity to load various sizes and chemistry of drugs. This review gives a brief overview of the diagnosis and current treatment strategies for PCa outlining their existing challenges. It critically analyzes the design, development and application of pure, modified and hybrid SBNPs based drug delivery systems in the treatment of PCa, their advantages and limitations.