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Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry
Author(s) -
Xie Xin,
Xiang Li,
Peng Cheng,
Han Bo
Publication year - 2019
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201800199
Subject(s) - pyrazolone , ring (chemistry) , enantioselective synthesis , combinatorial chemistry , catalysis , chemistry , raw material , material chemistry , organic chemistry , nanotechnology , green chemistry , materials science , reaction mechanism
Chiral spiropyrazolones are unique frameworks widely found in a large family of medicinally relevant compounds with various biological activities. Substantial research efforts have been invested toward stereoselectively by constructing spiro‐cyclic structures. Over the past years, remarkable progress has been made in the organo‐ and metal‐catalyzed asymmetric synthesis of spiropyrazolones through the utilization of accessible simple pyrazolone derivatives as raw materials. This review is organized according to the size of the spiro‐ring fused at the 4‐position of the pyrazolone framework. In the last part, the bio‐evaluations of chiral spiropyrazolones for drug discovery are summarized.