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Development of Chaetocin and S ‐Adenosylmethionine Analogues as Tools for Studying Protein Methylation
Author(s) -
Sohtome Yoshihiro,
Sodeoka Mikiko
Publication year - 2018
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201800118
Subject(s) - methylation , methyltransferase , rna methylation , computational biology , biology , dna methylation , substrate (aquarium) , chemistry , biochemistry , dna , gene , ecology , gene expression
Abstract Physiological regulatory mechanisms of protein, RNA, and DNA functions include small chemical modifications, such as methylation, which are introduced or removed in a highly chemo‐, regio‐, and site‐selective manner by methyltransferases and demethylases, respectively. However, mimicking or controlling these modifications by using labeling reagents and inhibitors remains challenging. In this Personal Account, we introduce our nascent interdisciplinary collaboration between chemists and biologists aimed at developing a basic strategy to analyse and control the methylation reactions regulated by protein methyltransferases (PMTs). We focus in particular on the structural development of chaetocin and S ‐adenosylmethionine to obtain PMT inhibitors and PMT substrate detectors.