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Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor
Author(s) -
Vámosi Péter,
Matsuo Keiya,
Masuda Tsuguya,
Sato Kohei,
Narumi Tetsuo,
Takeda Kazuhiro,
Mase Nobuyuki
Publication year - 2019
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201800048
Subject(s) - microwave , continuous flow , reaction conditions , process engineering , continuous reactor , microwave heating , flow (mathematics) , materials science , reaction rate , nuclear engineering , computer science , chemistry , mechanics , catalysis , engineering , physics , organic chemistry , telecommunications
Abstract Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a “9+4+1 method” to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.