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Design and Synthesis of Polycycles, Heterocycles, and Macrocycles via Strategic Utilization of Ring‐Closing Metathesis
Author(s) -
Kotha Sambasivarao,
Meshram Milind,
Dommaraju Yuvaraj
Publication year - 2018
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201800025
Subject(s) - ring closing metathesis , metathesis , cycloaddition , ring (chemistry) , salt metathesis reaction , combinatorial chemistry , chemistry , organic chemistry , catalysis , polymerization , polymer
In this perspective, we summarize new synthetic approaches for the construction of various polycyclic compounds involving ring‐closing metathesis as a key step. In this regard, we used ring‐closing metathesis in combination with other popular reactions like Suzuki‐Miyaura coupling, Claisen rearrangement, Fischer indolization, Grignard addition, Diels‐Alder reaction, and [2+2] cycloaddition reaction etc. To this end, a variety of functional molecules such as α‐amino acids, cyclophanes, heterocycles, propellanes, spirocycles, and macrocycles have been prepared. The strategies developed and the molecules prepared here play a key role in designing new materials and also act as lead compounds in drug design. The strategies and tactics developed here are useful to design polycycles, macrocycles, and heterocycles of diverse ring systems.