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Chemistry of Cyanide Adducts of Aldimines from Aniline Derivatives
Author(s) -
Park Eunjoon,
Jeon Jiye,
Cheon CheolHong
Publication year - 2018
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201800005
Subject(s) - adduct , cyanide , chemistry , hydrogen cyanide , aniline , aldimine , organic chemistry , indole test , catalysis
Abstract The chemistry of hydrogen cyanide adducts of imines is well‐developed, but that of cyanide adducts remains unexplored. This is presumably because these cyanide adducts are not stable and thus not readily available in their isolated forms. In this personal account, we present the progress made in our research program towards the development of novel organic transformations utilizing cyanide adducts of imines as key intermediates. We also report the application of these methodologies to the total synthesis of natural products including indole alkaloids.