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Manganese‐Mediated Homolytic Aromatic Substitution with Phosphinylidenes
Author(s) -
Berger Olivier,
Montchamp JeanLuc
Publication year - 2017
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201700021
Subject(s) - homolysis , manganese , substitution (logic) , chemistry , electrophilic aromatic substitution , medicinal chemistry , organic chemistry , radical , philosophy , linguistics
Carbon‐phosphorus (C−P) bond‐forming reactions via homolytic aromatic substitution (HAS) of non‐functionalized substrates with phosphinylidene P(O)H compounds is becoming a useful synthetic tool for the preparation of aryl and heteroaryl phosphonates, phosphinates, and phosphine oxides. This review specifically covers recent work using manganese‐mediated free radical processes. Several research groups employ expensive Mn(OAc) 3 , whereas our own contributions focus on the novel and inexpensive Mn(OAc) 2 /MnO 2 system.