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Functionalization of C‐H Bonds by Photoredox Catalysis
Author(s) -
Qin Qixue,
Jiang Heng,
Hu Zhentao,
Ren Daan,
Yu Shouyun
Publication year - 2017
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600125
Subject(s) - photoredox catalysis , surface modification , photochemistry , inert , photocatalysis , visible spectrum , catalysis , chemistry , trifluoromethylation , alkylation , combinatorial chemistry , organic chemistry , materials science , alkyl , optoelectronics , trifluoromethyl
Visible‐light photoredox catalysis has been successfully used in the functionalization of inert C−H bonds including C(sp 2 )‐H bonds of arenes and C(sp 3 )‐H bonds of aliphatic compounds over the past decade. These transformations are typically promoted by the process of single‐electron‐transfer (SET) between substrates and photo‐excited photocatalyst upon visible light irradiation (household bulbs or LEDs). Compared with other synthetic strategies, such as the transition‐metal catalysis and traditional radical reactions, visible‐light photoredox approach has distinct advantages in terms of operational simplicity and practicability. Versatile direct functionalization of inert C(sp 2 )‐H and C(sp 3 )‐H bonds including alkylation, trifluoromethylation, arylation and amidation, has been achieved using this practical strategy.