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Advancement in Catalytic Asymmetric Hydrogenation of Ketones and Imines, and Development of Asymmetric Isomerization of Allylic Alcohols
Author(s) -
Ohkuma Takeshi,
Arai Noriyoshi
Publication year - 2016
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600101
Subject(s) - isomerization , allylic rearrangement , catalysis , chemistry , stereoselectivity , asymmetric hydrogenation , ligand (biochemistry) , combinatorial chemistry , organic chemistry , optically active , enantioselective synthesis , biochemistry , receptor
Catalytic asymmetric hydrogenation of ketones through the “metal–ligand cooperative mechanism” has been improved in terms of the efficiency, stereoselectivity, and scope of substrates by varying the arrangement of the catalyst structure and reaction conditions. Imino compounds are also smoothly converted to the optically active amines with appropriate catalysts. This type of catalyst exhibits excellent performance on the asymmetric isomerization of primary allylic alcohols into the optically active aldehydes. This personal account describes recent progress on these topics.