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Divergent Total Synthesis of Atisane‐Type Diterpenoids
Author(s) -
Zhu Guili,
Wadavrao Sachin B.,
Liu Bo
Publication year - 2017
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600096
Subject(s) - total synthesis , stereochemistry , natural product , type (biology) , chemistry , diterpene , skeleton (computer programming) , terpene , biology , ecology , anatomy
Atisane‐type diterpenoids are the principal constituent of tetracyclic C 20 ‐diterpenoids, widely isolated from the plant kingdom with varying degrees of structural complexity and pharmacological activity. The tetracarbocyclic system with the unique bicyclo[2.2.2]octane skeleton of this natural product family has generated interest within the synthetic community. Divergent total synthesis is an effective tactic to synthesize several atisane‐type diterpenoids using structural interconversion from a common intermediate. This account summarizes the divergent total synthesis of atisane‐type diterpenoids.