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Photoactivatable Substrates: A Material‐Based Approach for Dissecting Cell Migration
Author(s) -
Nakanishi Jun
Publication year - 2017
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600090
Subject(s) - nanotechnology , cell migration , cell , tissue engineering , computer science , chemistry , biochemical engineering , computational biology , materials science , biology , engineering , biochemistry , genetics
Photoactivatable substrates, which show changes in surface cell adhesiveness in response to photoirradiation, are promising platforms for cell manipulation with high spatiotemporal resolution. In addition to having applications in cell and tissue engineering, these materials are unique tools for basic biological sciences research, and they complement conventional genetic engineering technologies. One of the most useful applications is in the study of cell migration, which occurs in various physiological and pathological processes. In this personal account, I provide a brief overview of the development of photoactivatable substrates and their applications, highlighting in particular the contributions of our research group to collective cell migration studies. This material‐based approach is useful for dissecting the molecular biological and mechanobiological aspects of the regulatory mechanisms in the cellular social activities.