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The Development of Phosphine‐Free "Tethered" Ruthenium(II) Catalysts for the Asymmetric Reduction of Ketones and Imines
Author(s) -
G. Nedden Hans,
ZanottiGerosa Antonio,
Wills Martin
Publication year - 2016
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600084
Subject(s) - ruthenium , phosphine , transfer hydrogenation , catalysis , asymmetric hydrogenation , chemistry , combinatorial chemistry , diamine , enantioselective synthesis , noyori asymmetric hydrogenation , ketone , organic chemistry
In this account, we describe the design, synthesis and applications of tethered versions of the Ru(II)/ N ‐tosyl‐1,2‐diphenylethylene‐1,2‐diamine (TsDPEN) class of catalyst that are commonly used for asymmetric transfer hydrogenation and asymmetric hydrogenation of ketones and imines. The review covers key aspects of the reaction mechanisms and examples of applications, including industrial applications to pharmaceutically important target molecules. In addition, closely related catalysts based on Rh(III) and Ir(III) are also described.