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Allylic Alkylations with Enamine Nucleophiles
Author(s) -
Butt Nicholas,
Yang Guoqiang,
Zhang Wanbin
Publication year - 2016
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600071
Subject(s) - enamine , nucleophile , tsuji–trost reaction , allylic rearrangement , chemistry , alkylation , organic chemistry , catalysis , organic synthesis , nucleophilic addition , combinatorial chemistry
Allylic alkylation reactions are some of the most important carbon‐carbon bond forming reactions in organic synthesis. In particular, the alkylation of carbonyl substrates provides an efficient pathway to structurally diverse molecules. Such reactions predominantly rely on the in situ generation of a nucleophilic enamine intermediate. This brief personal account describes research carried out in our group concerning the Pd‐catalyzed allylic alkylation of carbonyl compounds using these species. Our methodology combines Pd‐catalysis with metallocene ligands to carry out these transformations.