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Mild Palladium Catalyzed ortho C‐H Bond Functionalizations of Aniline Derivatives
Author(s) -
Tischler Ms. Orsolya,
Tóth Mr. Balázs,
Novák Zoltán
Publication year - 2017
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600059
Subject(s) - aniline , palladium , acylation , catalysis , alkylation , chemistry , combinatorial chemistry , organic chemistry , reaction conditions
This account collects the developments and transformations which avoid the utilization of harsh reaction conditions in the field of palladium catalyzed, ortho ‐directed C−H activation of aniline derivatives from the first attempts to up‐to‐date results, including the results of our research laboratory. The discussed functionalizations performed under mild conditions include acylation, olefination, arylation, alkylation, alkoxylation reactions. Beside the optimization studies and the synthetic applications mechanistic investigations are also presented.