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Hybrid Nanoparticles as Drug Carriers for Controlled Chemotherapy of Cancer
Author(s) -
Li Menghuan,
Luo Zhong,
Zhao Yanli
Publication year - 2016
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600029
Subject(s) - drug delivery , nanotechnology , drug , biocompatibility , biosafety , nanoparticle , targeted drug delivery , drug carrier , materials science , computer science , biochemical engineering , medicine , microbiology and biotechnology , pharmacology , engineering , biology , metallurgy
Rapid developments in materials science and biological mechanisms have greatly boosted the research discoveries of new drug delivery systems. In the past few decades, hundreds of nanoparticle‐based drug carriers have been reported almost on a daily basis, in which new materials, structures, and mechanisms are proposed and evaluated. Standing out among the drug carriers, the hybrid nanoparticle systems offer a great opportunity for the optimization and improvement of conventional chemotherapy. By combining several features of functional components, these hybrid nanoparticles have shown excellent promises of improved biosafety, biocompatibility, multifunctionality, biodegradability, and so forth. In this Personal Account, we highlight the recent research advances of some representative hybrid nanoparticles as drug delivery systems and discuss their design strategies and responsive mechanisms for controlled drug delivery.