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D‐Peptides as Recognition Molecules and Therapeutic Agents
Author(s) -
Liu Min,
Li Xue,
Xie Zuoxu,
Xie Cao,
Zhan Changyou,
Hu Xuefeng,
Shen Qing,
Wei Xiaoli,
Su Bingxia,
Wang Jing,
Lu Weiyue
Publication year - 2016
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201600005
Subject(s) - peptide , bioavailability , chemistry , receptor , computational biology , pharmacology , biochemistry , biology
Over recent years, D‐peptides have attracted increasing attention. D‐peptides increase enzymatic stability, prolong the plasma half‐life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L‐peptide. Therefore, D‐peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D‐peptides with biological activity.