Domino Reactions Based on Combinatorial Bond Transformations in Electron‐Deficient Tertiary Enamines

Electron‐deficient enamines such as enaminones and enaminoesters are moieties showing widespread application in organic synthesis. Among the various available electron‐deficient enamines, the N , N ‐disubstituted amino‐functionalized ones (tertiary enamines) represent a class of special enamines with distinct properties and important applications. Based on our longstanding interest in exploring novel synthetic methods using electron‐deficient tertiary enamines, we present herein the research advances in organic synthesis via domino reactions making use of the combinatorial C–N, C=C, C–H, and other bond transformations of electron‐deficient tertiary enamines.