Harnessing the Versatility of Continuous‐Flow Processes: Selective and Efficient Reactions

There is a great need for effective transformations and a broad range of novel chemical entities. Continuous‐flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas–liquid–solid and liquid–solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3‐triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid‐phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid.