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A Personal History of Quadruplex–Small Molecule Targeting
Author(s) -
Neidle Stephen
Publication year - 2015
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201500011
Subject(s) - g quadruplex , small molecule , context (archaeology) , rational design , computational biology , dna , molecule , nanotechnology , chemistry , biology , genetics , materials science , paleontology , organic chemistry
The story behind some of the early studies in the laboratory of Stephen Neidle on quadruplex‐binding small molecules and the structural studies on quadruplexes and their complexes is presented and discussed in the context of his earlier work on drug–DNA interactions. More recent studies and future directions in the rational design of small molecules targeting telomeric and gene promoter quadruplexes are also described.