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Recent Advances in the Base‐Induced Sommelet–Hauser Rearrangement of Amino Acid Derived Ammonium Ylides
Author(s) -
Tayama Eiji
Publication year - 2015
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201500009
Subject(s) - ammonium , base (topology) , chemistry , amino acid , stereochemistry , biochemistry , organic chemistry , mathematics , mathematical analysis
The Sommelet–Hauser rearrangement of N ‐benzylic ammonium ylides generated from ammonium salts is an interesting and useful transformation that enables one to convert a readily accessible C–N bond into a new C–C bond to an aromatic ring. The rearrangement was discovered by Sommelet in 1937, studied in detail by Hauser, and applied to organic synthesis by Sato until 1999. Further studies have not advanced because several competitive side reactions and structural limitations of the products severely limit the substrate scope and synthetic applications. In this Personal Account, a history of the research in problem solving and recent advances in the base‐induced Sommelet–Hauser rearrangement are described. This synthetic method developed by my group provides efficient access to various types of α‐aryl‐α‐amino acid and α‐aryl‐β‐amino acid derivatives.