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Stereoselective Electrophilic Cyclization
Author(s) -
Sakakura Akira,
Ishihara Kazuaki
Publication year - 2015
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201500005
Subject(s) - electrophile , enantioselective synthesis , stereoselectivity , nucleophile , chemistry , lewis acids and bases , combinatorial chemistry , catalysis , organic chemistry
Electrophilic cyclizations of unactivated alkenes play highly important roles in the synthesis of useful building blocks. This account describes our contributions to the rational design of monofunctionalized chiral Lewis base catalysts for enantioselective iodo‐ and protocyclizations. For the stereoselective promotion of electrophilic bromocyclizations, nucleophilic phosphite–urea cooperative catalysts have been designed.