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Diversity‐Oriented Approach for Chemical Biology
Author(s) -
Lee JunSeok,
Lee Jae Wook,
Kang Namyoung,
Ha HyungHo,
Chang YoungTae
Publication year - 2015
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201402087
Subject(s) - diversity (politics) , chemical biology , identification (biology) , computational biology , biology , chemical genetics , synthetic biology , perspective (graphical) , data science , computer science , small molecule , nanotechnology , biochemical engineering , artificial intelligence , engineering , ecology , genetics , materials science , sociology , anthropology
Synthetic molecules that modulate and probe biological events are critical tools in chemical biology. Utilizing combinatorial and diversity‐oriented synthetic strategies, access to large numbers of small molecules is becoming more and more feasible, and research groups in this field can take advantage of the power of chemical diversity. Since the majority of early studies were focused on the discovery of compounds that perturb protein functions, diversity‐based approaches are often considered as therapeutic lead discovery tactics. However, the diversity‐oriented approach can also be applied to advance distinct aims, such as target protein identification, or the development of imaging probes and sensors. This review provides a personal perspective of the chemical‐diversity‐based approach and how this principle can be adapted to various chemical biology studies.