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Reductive Umpolung Reactions with Low‐Valent Titanium Catalysts
Author(s) -
Streuff Jan
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201402058
Subject(s) - umpolung , catalysis , stereoselectivity , titanium , reductive elimination , combinatorial chemistry , coupling reaction , chemistry , coupling (piping) , carbon fibers , materials science , organic chemistry , metallurgy , nucleophile , composite number , composite material
The coupling of similarly polarized carbon fragments can be achieved by a reductive umpolung strategy. This gives access to compounds with functional groups in even bond distances, which are difficult to synthesize by other means. Low‐valent titanium catalysts enable such couplings under mild conditions. This account covers the recent progress on this topic with a focus on the development of cross‐selective coupling reactions and stereoselective examples.