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A Journey to the Total Synthesis of Daptomycin
Author(s) -
Lam Hiu Yung,
Gaarden Rannveig Ingebrigtsen,
Li Xuechen
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201402049
Subject(s) - daptomycin , threonine , antibiotics , serine , total synthesis , chemistry , stereochemistry , biology , biochemistry , phosphorylation , bacteria , vancomycin , genetics , staphylococcus aureus
Daptomycin, the first antibiotic of its class, provides a new structural motif for the development of new antibiotics. Recently, we have completed the total synthesis of daptomycin. The development of the successful synthetic strategy is described here, including the application of serine/threonine ligation mediated peptide cyclization to the daptomycin macrocyclization.