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Late‐Stage Formation of Carbon–Fluorine Bonds
Author(s) -
Campbell Michael G.,
Ritter Tobias
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201402016
Subject(s) - fluorine , stage (stratigraphy) , carbon fibers , positron emission tomography , molecule , work (physics) , nanotechnology , chemistry , materials science , organic chemistry , engineering , nuclear medicine , geology , composite material , mechanical engineering , medicine , paleontology , composite number
In this account, we review work from our lab on the development of methods for carbon–fluorine bond formation, with an emphasis on late‐stage fluorination of functionalized small molecules and synthesis of 18 F‐labeled molecules for potential use as tracers in positron emission tomography ( PET ). We attempt to highlight reactions that we feel are of particular practical relevance, as well as areas of research where there is still significant room for advancement.