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Efficient Total Synthesis of Bioactive Natural Products: A Personal Record
Author(s) -
Zhang Yun,
Gong Jianxian,
Yang Zhen
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201402015
Subject(s) - total synthesis , synthetic biology , computer science , perspective (graphical) , natural (archaeology) , diversity (politics) , nanotechnology , biochemical engineering , combinatorial chemistry , chemistry , computational biology , biology , artificial intelligence , organic chemistry , engineering , materials science , sociology , paleontology , anthropology
Abstract In this account, we have highlighted our most recent works towards the total synthesis of bioactive natural products, which have resulted in the development of several novel synthetic methods. Inspired and guided by strategies based on diversity‐oriented synthesis, we have successfully applied the novel synthetic methodologies developed in our lab to the total synthesis of a diverse collection of structurally challenging targets. We have also documented the evolution of these synthetic strategies. The total syntheses described in this account have been organized from the perspective of different molecules whilst still alluding to the parallel synthetic strategies involved.