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Endeavors to Access Molecular Complexity: Strategic Use of Free Radicals in Natural Product Synthesis
Author(s) -
Yoshimitsu Takehiko
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201300024
Subject(s) - radical , natural product , organic synthesis , chemistry , natural (archaeology) , combinatorial chemistry , nanotechnology , biochemical engineering , computer science , organic chemistry , catalysis , materials science , engineering , biology , paleontology
Free radicals, which in the past were considered unruly chemical species, have become manageable and indispensable for synthetic organic chemistry. The unique nature of free radicals has allowed practitioners in organic synthesis to design flexible approaches to produce various materials ranging from small molecules to polymers. The present Personal Account describes the author's endeavors to create molecular complexity by the strategic use of free radicals, with an emphasis on the synthesis of bioactive natural products.