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Triazole‐Linked Analogues of DNA and RNA ( TL DNA and TL RNA ): Synthesis and Functions
Author(s) -
Isobe Hiroyuki,
Fujino Tomoko
Publication year - 2014
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201300023
Subject(s) - rna , oligonucleotide , dna , nuclease , click chemistry , chemistry , duplex (building) , combinatorial chemistry , stereochemistry , computational biology , biology , biochemistry , gene
Click chemistry has provided us with access to DNA and RNA analogues with non‐natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non‐cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole‐linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.