Asymmetric  M ukaiyama Aldol Reactions Using Chiral Diamine–Coordinated   Sn (II)  Triflate: Development and Application to Natural Product Synthesis | Zendy

Shiina Isamu | Zendy

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Asymmetric M ukaiyama Aldol Reactions Using Chiral Diamine–Coordinated Sn (II) Triflate: Development and Application to Natural Product Synthesis

Author(s) -

Shiina Isamu

Publication year - 2014

Publication title -

the chemical record

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.61

H-Index - 78

eISSN - 1528-0691

pISSN - 1527-8999

DOI - 10.1002/tcr.201300022

Subject(s) - aldol reaction , trifluoromethanesulfonate , diamine , chemistry , total synthesis , lewis acid catalysis , natural product , lewis acids and bases , organic chemistry , catalysis

In 1989, the asymmetric M ukaiyama aldol reaction mediated by a Lewis acid consisting of a chiral diamine and Sn (II) triflate was reported. The asymmetric M ukaiyama aldol reaction is now widely used as a versatile tool for the construction of highly advanced, multifunctionalized molecules. In this P ersonal A ccount, the history of the development of this powerful methodology and the application of the asymmetric M ukaiyama aldol reaction in the synthesis of natural products are reviewed.

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