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Marine cytotoxic macrolides haterumalides and biselides, and related natural products
Author(s) -
Kigoshi Hideo,
Hayakawa Ichiro
Publication year - 2007
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.20119
Subject(s) - cytotoxicity , cytotoxic t cell , natural product , natural (archaeology) , cancer cell lines , biology , stereochemistry , chemistry , cancer , cancer cell , biochemistry , genetics , in vitro , paleontology
Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14‐membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products. © 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 7: 254–264; 2007: Published online in Wiley InterScience ( www.interscience.wiley.com ) DOI 10.1002/tcr.20119