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Lessons from total synthesis of hybrid natural products
Author(s) -
Suzuki Keisuke
Publication year - 2010
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.201000030
Subject(s) - biochemical engineering , total synthesis , natural (archaeology) , computer science , computational biology , combinatorial chemistry , nanotechnology , chemistry , biology , organic chemistry , engineering , materials science , paleontology
There are a vast number of interesting and useful compounds that are readily found in nature. Mother Nature has acquired ingenious ways of generating molecular diversity in living cells responsible for regulation of various biochemical events. This has inspired research into the synthesis of biologically active compounds for use as antibiotics or in cancer therapy, for example. This account provides an overview of the work performed in the total synthesis of hybrid natural products and the interesting synthetic mechanisms encountered along the way. © 2010 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Published online in Wiley InterScience ( www.interscience.wiley.com ) DOI 10.1002/tcr.201000030