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Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts
Author(s) -
Kusumoto Shoichi,
Fukase Koichi
Publication year - 2006
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.20098
Subject(s) - lipid a , lipopolysaccharide , innate immune system , immune system , receptor , chemistry , homogeneous , bacteria , gram negative bacteria , biology , biochemistry , immunology , physics , escherichia coli , thermodynamics , genetics , gene
A new stage of endotoxin research was brought about by structure elucidation and chemical synthesis of lipid A, the lipophilic partial structure of the lipopolysaccharide (LPS) of Gram‐negative bacteria. Synthetic lipid A exhibited full endotoxic activity, which gave unequivocal evidence for the concept that lipid A is the active entity of endotoxin. Various lipid A analogues, as well as their radiolabeled derivatives and more complex partial structures of LPS, were also synthesized. By the use of these synthetic homogeneous preparations, not only simple studies on structure–activity relationships but precise and detailed analyses became possible on how this typical bacterial component is recognized by the innate immune receptor complex of mammalian cells. © 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 6: 333–343; 2006: Published online in Wiley InterScience ( www.interscience.wiley.com ) DOI 10.1002/tcr.20098