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2′‐deoxy′4′‐ C ‐ethynyl‐2‐fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity
Author(s) -
Ohrui Hiroshi
Publication year - 2006
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.20078
Subject(s) - nucleoside reverse transcriptase inhibitor , reverse transcriptase , virology , reverse transcriptase inhibitor , nucleoside , nucleoside analogue , human immunodeficiency virus (hiv) , toxicity , antiretroviral therapy , medicine , chemistry , stereochemistry , rna , viral load , biochemistry , gene
An idea to use 4′‐ C ‐substituted‐2′‐deoxynucleoside derivatives was proposed based on a working hypothesis to solve the problems of existing acquired immune deficiency syndrome chemotherapy (highly active antiretroviral therapy). Subsequent studies have successfully proved the validity of the idea and resulted in the development of 2′‐deoxy‐4′‐ C ‐ethynyl‐2‐fluoroadenosine, a nucleoside reverse transcriptase inhibitor, which is highly potent to all human immunodeficiency viruses type 1 (HIV‐1s) including multidrug‐resistant HIV‐1 and has a low toxicity. © 2006 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 6: 133–143; 2006: Published online in Wiley InterScience ( www.interscience.wiley.com ) DOI 10.1002/tcr.20078