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Functional tuning of nucleic acids by chemical modifications: Tailored oligonucleotides as drugs, devices, and diagnostics
Author(s) -
Verma Sandeep,
Jäger Stefan,
Thum Oliver,
Famulok Michael
Publication year - 2003
Publication title -
the chemical record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.61
H-Index - 78
eISSN - 1528-0691
pISSN - 1527-8999
DOI - 10.1002/tcr.10047
Subject(s) - nucleic acid , oligonucleotide , biomolecule , chemistry , combinatorial chemistry , rna , nucleobase , nanotechnology , biochemistry , dna , materials science , gene
Chemical modifications of nucleic acids present vast opportunities for extending the functions and properties of these biomolecules. In general, efforts invested in this direction pertain to the introduction of reactive functional groups for further derivatizations of oligonucleotides with numerous reporter groups and for equipping nucleic acids with catalytic chemical moieties. This review deals with representative chemical modifications in the nucleobases, sugars, and the phosphate ester backbone and their application from novel catalytic RNA selection to nucleic acid‐based biosensors. © 2003 The Japan Chemical Journal Forum and Wiley Periodicals, Inc., Chem Rec 3: 51–60; 2003: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.10047