Open AccessApplication of 5‐aminolevulinic acid‐photodynamic therapy in common skin diseases
Author(s) -
Shi Lei,
Liu Pei,
Liu Jia,
Yang Yuling,
Chen Qi,
Zhang Yunfeng,
Zhang Haiyan,
Wang Xiuli
Publication year - 2020
Publication title -
translational biophotonics
Language(s) - English
Resource type - Journals
ISSN - 2627-1850
DOI - 10.1002/tbio.201900028
Subject(s) - photodynamic therapy , stratum corneum , protoporphyrin ix , dermatology , actinic keratosis , medicine , actinic keratoses , acne , keratosis , protoporphyrin , intense pulsed light , pathology , chemistry , porphyrin , organic chemistry , photochemistry , basal cell
5‐Aminolevulinic acid‐photodynamic therapy (ALA‐PDT) is a relatively novel therapeutic technique that is used widely in dermatology. ALA can penetrate the stratum corneum into the skin and convert to the protoporphyrin IX (PpIX) to exert the photodynamic response. Due to its advantages of allowing repetitive application to multiple lesions, non‐trauma and excellent cosmetic results, ALA‐PDT is widely used for the treatment of actinic keratosis, moderate and severe acne, condyloma acuminate and other skin diseases showing a strong or promising effectiveness. However, pain is the main adverse reaction of ALA‐PDT. Daylight PDT (D‐PDT) and an optimized PDT may relieve the pain through the change of light source and therapeutic parameters. Both will be the tendency of the clinical application of ALA‐PDT.