Open AccessFluorescence visualization of the borders of bladder tumors after TUR with quantitative determination of diagnostic contrast
Author(s) -
Loshchenov Maxim,
Seregin Alexander,
Kalyagiina,
Dadashev Elmar,
Borodkin Alexander,
Babaev Akobirkhon,
Loran Oleg,
Loschenov Victor
Publication year - 2020
Publication title -
translational biophotonics
Language(s) - English
Resource type - Journals
ISSN - 2627-1850
DOI - 10.1002/tbio.201900026
Subject(s) - cystoscopy , fluorescence , excitation wavelength , contrast (vision) , bladder cancer , resection , bladder tumor , pathology , radiology , medicine , materials science , optics , cancer , surgery , physics , alternative medicine
The study demonstrates the ability of fluorescence diagnosis to perform intraoperative analysis of the bladder wall. The data of 10 patients with superficial bladder cancer who underwent PDD with the use of the fluorescence video system with excitation wavelenght in the “red” wavelength range and TUR is discussed. General condition of the bladder is assessed, the main foci of the tumor are determined. Then a tumor resection is performed. Further examination and identification of the fluorescing boundaries of the tumor remaining after TUR is performed to make a decision of a re‐resection. In addition, small fluorescing tumor foci, not detected with WL cystoscopy, are detected. Moreover the diagnostic fluorescence contrast is measured, allowing quantitative assessment of the 5‐ALA accumulation in tissues. The applied laser wavelength of 635 nm allows the light to penetrate deeper into the bladder tissue, making it possible to detect tumors including in the deeper layers.