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Multivesicular Vesicles: Preparation and Applications
Author(s) -
Giuliano Camila Betterelli,
Cvjetan Nemanja,
Ayache Jessica,
Walde Peter
Publication year - 2021
Publication title -
chemsystemschem
Language(s) - English
Resource type - Journals
ISSN - 2570-4206
DOI - 10.1002/syst.202000049
Subject(s) - vesicle , amphiphile , bilayer , nanotechnology , drug delivery , chemistry , protocell , lipid vesicle , artificial cell , biophysics , materials science , membrane , biology , copolymer , biochemistry , organic chemistry , polymer
Multivesicular vesicles, i. e. vesicles containing internal, non‐concentrically arranged smaller vesicles, are artificial, polymolecular compartment systems, which can be prepared from naturally occurring or fully synthetic bilayer‐forming amphiphiles in aqueous solution through various guided assembly procedures. The general concepts for the preparation of such “vesicles‐inside‐vesicles” systems (also called “vesosomes”) are summarized, and the different methods used are compared. Selected applications of multivesicular vesicles in the field of drug delivery, cell‐mimicking model systems, and as versatile compartments for the investigation of confined reactions are discussed.