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The Dynamics of an Oscillating Enzymatic Reaction Network is Crucially Determined by Side Reactions
Author(s) -
Pogodaev Aleksandr A.,
Lap Tijs T.,
Huck Wilhelm T. S.
Publication year - 2021
Publication title -
chemsystemschem
Language(s) - English
Resource type - Journals
ISSN - 2570-4206
DOI - 10.1002/syst.202000033
Subject(s) - biological system , resilience (materials science) , perturbation (astronomy) , computer science , biochemical engineering , chemistry , chemical physics , control theory (sociology) , statistical physics , computational chemistry , physics , thermodynamics , engineering , artificial intelligence , biology , control (management) , quantum mechanics
Synthetic complex chemical systems are often subject to perturbations in reaction conditions. To ensure robust functioning of these systems in real‐world applications, a better understanding is required of how resilience to perturbations could be included in the design of these systems. In order to develop such an understanding we need a deeper insight into how chemical systems respond to perturbations. Here, we study the effect of spiking concentrations in an oscillating enzymatic reaction network. We identify that a different magnitude of a perturbation triggers two distinctive responses: obtaining sustained oscillations and causing the loss of the amplitude. We rationalise our findings based on non‐linear dynamics and identify that non‐essential side reactions crucially tailor the observed behaviour.