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Biochemical and electrophysiological effects of 7‐OH‐DPAT on the mesolimbic dopaminergic system
Author(s) -
Devoto Paola,
Collu Maria,
Muntoni Anna Lisa,
Pistis Marco,
Serra Gino,
Gessa Gian Luigi,
Diana Marco
Publication year - 1995
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890200209
Subject(s) - nucleus accumbens , dopamine , dopaminergic , autoreceptor , chemistry , ventral tegmental area , agonist , stimulation , electrophysiology , neuroscience , dopamine receptor d3 , medicine , endocrinology , receptor , biology , biochemistry
Systemic administration of the putative selective D 3 receptor agonist 7‐hydroxy‐2‐(N, N‐di‐ n ‐propylamino)tetralin(7‐OH‐DPAT) consistently decreased extracellular dopamine and 3,4‐dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens and dopaminergic neuronal activity in the ventral tegmental area. 7‐OH‐DPAT inhibited dopamine release in the nucleus accumbens also when locally perfused through the dialysis probe. The results suggest the possibility that stimulation of dopamine D 2 receptors with 7‐OH‐DPAT mimic biochemical and electrophysiological actions previously ascribed to D 2 autoreceptor stimulation; however the lack of selective D 3 antagonist precludes any firm conclusion in this sense. © 1995 Wiley‐Liss, Inc.