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Insulin‐like growth factor‐I receptors in human brain and pituitary gland: An autoradiographic study
Author(s) -
De Keyser Jacques,
Wilczak Nadine,
De Backer JeanPaul,
Herroelen Luc,
Vauquelin G.
Publication year - 1994
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890170309
Subject(s) - endocrinology , medicine , pituitary gland , nucleus accumbens , biology , receptor , hippocampus , cerebellum , anterior olfactory nucleus , substantia nigra , neuroscience , olfactory tubercle , chemistry , central nervous system , dopamine , hormone , dopaminergic
Insulin‐like growth factor (IGF)‐I receptors were studied in adult human postmortem brain and pituitary gland using quantitative autoradiography with human recombinant [ 125 I]IGF‐I. The highest densities were found in the choroid plexus, pituitary gland‐where IGF‐I receptors were mainly concentrated in the anterior lobe, pineal gland, glomerular layer of the olfactory bulb, and the molecular layer of the cerebellar cortex. Moderate densities were present in cerebral cortex, caudate nucleus, putamen, accumbens, the CA1, CA2, CA3 fields and dentate gyrus of the hippocampus, the dendate nucleus of the cerebellum, amygdala, thalamus, pontine nuclei, and substantia nigra. All other brain areas, including white matter, contained low densities of IGF‐I receptors. The finding that several well‐defined brain structures are enriched with IGF‐I receptors suggests a rieurotrophic/survival or neuromodulatory role of insulin‐like growth factors on specific neuronal systems. IGF‐I receptors observed in the white matter may be associated with oligodendrocytes. © 1994 Wiley‐Liss, Inc.