Loss of paired‐pulse facilitation at the corticostriatal synapse of the aged rat | Zendy

Walsh John P. | Zendy; Ou Xiaorong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Loss of paired‐pulse facilitation at the corticostriatal synapse of the aged rat

Author(s) -

Walsh John P.,

Ou Xiaorong

Publication year - 1994

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.890170105

Subject(s) - facilitation , synapse , neuroscience , neural facilitation , stimulation , synaptic augmentation , synaptic fatigue , synaptic plasticity , corpus callosum , pulse (music) , biology , chemistry , psychology , excitatory postsynaptic potential , physics , receptor , inhibitory postsynaptic potential , biochemistry , detector , optics

Changes in calcium (Ca 2+ ) homeostasis have been proposed to contribute to the aging process. Paired‐pulse facilitation, a form of synaptic enhancement that relies upon an accumulation of Ca 2+ in the presynaptic terminal, was used to examine the effect of aging at the corticostriatal synapse. Intracellular recordings in striatal neurons from young rats demonstrated a consistent enhancement in the second of two synaptic responses evoked by stimulation of the corpus callosum. In contrast, neurons from aged rats showed a consistent depression of the second synaptic response at identical pairing intervals. These differences were not explained by an age‐dependent increase in synaptic depression and demonstrate an alteration in the Ca 2+ ‐mediated process of presynaptic facilitation. © 1994 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research